In people who are deficient in CYP2D6, coadministration of modafinil with substrates of CYP2D6 that have ancillary routes of elimination by CYP2C19 (eg, tricyclic antidepressants and selective serotonin reuptake inhibitors) may bring about elevated circulating levels of these medicine and have to have dose adjustment (Robertson et al 2000; PROVIGIL

- Det illustrerer at morfin brukt ved kroniske smerter ofte gir pasienten ytterligere problemer. Dette er reflektert i mange veiledere om bruk av opioider. Person kan få relativt ødelagte liv uten stor smertelindring.Melde fra om alvorlige hendelser i helsetjenesten Korrigerende sikkerhetstiltak på utstyr i helsetjenesten Håndtering av medisins

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